| USD ($) $ in Millions, shares in Thousands | LTM | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 | Dec 31, 2015 | Dec 31, 2014 | Dec 31, 2013 | Dec 31, 2012 | Dec 31, 2011 | Dec 31, 2010 | Dec 31, 2009 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue | $ 79,665 | $ 65,179 | $ 45,043 | $ 34,124 | ||||||||||||||
Costs, expenses, and other: | ||||||||||||||||||
Cost of sales | 13,225 | 11,052 | 8,418 | 7,082 | ||||||||||||||
Research and development | 14,596 | 13,337 | 10,991 | 9,313 | ||||||||||||||
Marketing, selling, and administrative | 12,236 | 11,094 | 8,594 | 7,403 | ||||||||||||||
Acquired in-process research and development | 4,544 | 2,910 | 3,280 | 3,800 | ||||||||||||||
Acquired in-process research and development and development milestones (Note 3) | - | - | - | - | ||||||||||||||
Asset impairment, restructuring, and other special charges | 1,431 | 484 | 861 | 68 | ||||||||||||||
Other—net, (income) expense | (37) | (571) | (219) | 97 | ||||||||||||||
Costs, expenses, and other | 46,070 | 39,448 | 32,362 | 27,570 | ||||||||||||||
Income before income taxes | 33,595 | 25,731 | 12,680 | 6,555 | ||||||||||||||
Income taxes | 6,884 | 5,091 | 2,090 | 1,314 | ||||||||||||||
Net income from continuing operations | - | - | - | - | ||||||||||||||
Net income from discontinued operations (Note 19) | - | - | - | - | ||||||||||||||
Net income | $ 26,711 | $ 20,640 | $ 10,590 | $ 5,240 | ||||||||||||||
Earnings per share - basic and diluted | - | - | - | - | ||||||||||||||
Earnings per share: | ||||||||||||||||||
Earnings from continuing operations - basic (in usd per share) | - | - | - | - | ||||||||||||||
Earnings from discontinued operations - basic (in usd per share) | - | - | - | - | ||||||||||||||
Basic (in dollars per share) | 29.85 | 23 | 11.76 | 5.82 | ||||||||||||||
Earnings from continuing operations - diluted (in usd per share) | - | - | - | - | ||||||||||||||
Earnings from discontinued operations - diluted (in usd per share) | - | - | - | - | ||||||||||||||
Diluted (in dollars per share) | $ 29.79 | $ 22.95 | $ 11.71 | $ 5.8 | ||||||||||||||
Shares used in calculation of earnings per share: | ||||||||||||||||||
Basic (in shares) | 893,500 | 897,300 | 900,605 | 900,181 | ||||||||||||||
Diluted (in shares) | 894,800 | 899,300 | 904,059 | 903,284 |