| USD ($) $ in Millions, shares in Millions | LTM | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 | Dec 31, 2015 | Dec 31, 2014 | Dec 31, 2013 | Dec 31, 2012 | Dec 31, 2011 | Dec 31, 2010 | Dec 31, 2009 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||||||||||
Product sales | - | - | - | - | ||||||||||||||
Total revenues | 38,095 | 36,751 | 33,424 | 28,190 | ||||||||||||||
Other revenues | - | - | - | - | ||||||||||||||
Operating expenses: | ||||||||||||||||||
Cost of sales | 11,613 | 12,037 | 12,858 | 8,451 | ||||||||||||||
Cost of sales (excludes amortization of certain acquired intangible assets presented separately) | - | - | - | - | ||||||||||||||
Research and development | 7,629 | 7,272 | 5,964 | 4,784 | ||||||||||||||
Acquired in-process research and development | - | - | - | 0 | ||||||||||||||
Selling, general and administrative | 7,019 | 7,050 | 7,096 | 6,179 | ||||||||||||||
Amortization of certain acquired intangible assets | - | - | - | - | ||||||||||||||
Other | 408 | 1,312 | 248 | 879 | ||||||||||||||
Total operating expenses | 26,669 | 27,671 | 26,166 | 20,293 | ||||||||||||||
Operating income | 11,426 | 9,080 | 7,258 | 7,897 | ||||||||||||||
Other income (expense): | ||||||||||||||||||
Interest expense, net | 2,668 | 2,755 | 3,155 | 2,875 | ||||||||||||||
Other income, net | 1,529 | 2,651 | 506 | 2,833 | ||||||||||||||
Total income before income taxes | 10,287 | 8,976 | 4,609 | 7,855 | ||||||||||||||
Provision for income taxes | 1,544 | 1,265 | 519 | 1,138 | ||||||||||||||
Net income | $ 8,743 | $ 7,711 | $ 4,090 | $ 6,717 | ||||||||||||||
Earnings per share: | ||||||||||||||||||
Basic (in usd per share) | $ 16.22 | $ 14.33 | $ 7.62 | $ 12.56 | ||||||||||||||
Diluted (in usd per share) | $ 16.1 | $ 14.23 | $ 7.56 | $ 12.49 | ||||||||||||||
Weighted-average shares used in the calculation of earnings per share: | ||||||||||||||||||
Basic (in shares) | 540 | 538 | 537 | 535 | ||||||||||||||
Diluted (in shares) | 544 | 542 | 541 | 538 |