| USD ($) $ in Millions | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 | Dec 31, 2015 | Dec 31, 2014 | Dec 31, 2013 | Dec 31, 2012 | Dec 31, 2011 | Dec 31, 2010 | Dec 31, 2009 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating Activities: | |||||||||||||||||
Net income | $ 8,510 | $ 480 | $ 5,613 | ||||||||||||||
Adjustments to reconcile Net income to Net cash provided by operating activities: | |||||||||||||||||
Depreciation expense | 370 | 381 | 354 | ||||||||||||||
Amortization expense | 2,390 | 2,386 | 2,339 | ||||||||||||||
Stock-based compensation expense | 894 | 835 | 766 | ||||||||||||||
Deferred income taxes | 160 | (1,844) | (962) | ||||||||||||||
In-process research and development impairments | 590 | 4,180 | 50 | ||||||||||||||
Excess tax benefits from stock-based compensation | - | - | - | ||||||||||||||
Tax benefits from exercise and vesting of stock-based awards | - | - | - | ||||||||||||||
Tax Benefit from Employee Stock Plans | - | - | - | ||||||||||||||
Tax Benefits from Employee Stock Plans | - | - | - | ||||||||||||||
Net (gain) loss from equity securities | (451) | 274 | 167 | ||||||||||||||
Acquired in-process research and development expenses | 1,024 | 4,663 | 1,155 | ||||||||||||||
Up-front and milestone expense related to collaborative and other arrangements | - | - | - | ||||||||||||||
Write-downs for slow-moving and excess raw material and work in process inventory | - | - | - | ||||||||||||||
Write-downs for slow moving and excess raw material and work in process inventory | - | - | - | ||||||||||||||
Other, net | 480 | 353 | 826 | ||||||||||||||
Change in fair value of contingent consideration | - | - | - | ||||||||||||||
Other non-cash transactions | - | - | - | ||||||||||||||
Changes in operating assets and liabilities: | |||||||||||||||||
Accounts receivable, net | (367) | 139 | 157 | ||||||||||||||
Inventories | (1,036) | (426) | (842) | ||||||||||||||
Prepaid expenses and other | (311) | (259) | 39 | ||||||||||||||
Accounts payable | (132) | 290 | (347) | ||||||||||||||
Income tax assets and liabilities, net | (2,108) | (732) | (1,768) | ||||||||||||||
Income taxes payable | - | - | - | ||||||||||||||
Accrued and other liabilities | 6 | 108 | 458 | ||||||||||||||
Deferred revenues | - | - | - | ||||||||||||||
Net cash provided by operating activities | 10,019 | 10,828 | 8,006 | ||||||||||||||
Investing Activities: | |||||||||||||||||
Purchases of marketable debt securities | (3,939) | (244) | (1,930) | ||||||||||||||
Proceeds from sales of marketable debt securities | 854 | 2,265 | 510 | ||||||||||||||
Purchases of marketable securities | - | - | - | ||||||||||||||
Proceeds from sales of marketable debt securities | - | - | - | ||||||||||||||
Proceeds from maturities of marketable debt securities | 55 | 327 | 1,334 | ||||||||||||||
Acquisitions, including in-process research and development, net of cash acquired | (1,070) | (4,840) | (1,152) | ||||||||||||||
Up-front and milestone payments related to collaborative and other arrangements | - | - | - | ||||||||||||||
Purchases of equity securities | (133) | (492) | (442) | ||||||||||||||
Purchases of property, plant and equipment | (563) | (523) | (585) | ||||||||||||||
Other investing activities, net | 2 | 58 | (1) | ||||||||||||||
Net cash used in investing activities | (4,793) | (3,449) | (2,265) | ||||||||||||||
Financing Activities: | |||||||||||||||||
Proceeds from debt financing, net of issuance costs | 0 | 3,464 | 1,980 | ||||||||||||||
Proceeds from convertible note hedges | - | - | - | ||||||||||||||
Purchases of convertible note hedges | - | - | - | ||||||||||||||
Proceeds from issuances of senior notes, net of issuance costs | - | - | - | ||||||||||||||
Proceeds from issuances of convertible notes, net of issuance costs | - | - | - | ||||||||||||||
Proceeds from Sale of Warrants | - | - | - | ||||||||||||||
Proceeds from credit facility | - | - | - | ||||||||||||||
Repayments of credit facility | - | - | - | ||||||||||||||
Proceeds from issuances of common stock | 408 | 422 | 232 | ||||||||||||||
Repurchases of common stock under repurchase programs | (1,922) | (1,150) | (1,000) | ||||||||||||||
Repayments of debt and other obligations | (1,788) | (1,970) | (2,250) | ||||||||||||||
Payments to settle warrants | - | - | - | ||||||||||||||
Extinguishment of long-term debt | - | - | - | ||||||||||||||
Repayments of other long-term obligations | - | - | - | ||||||||||||||
Excess tax benefits from stock-based compensation | - | - | - | ||||||||||||||
Payment of contingent consideration | - | - | - | ||||||||||||||
Payments of dividends | (4,003) | (3,918) | (3,809) | ||||||||||||||
Other financing activities, net | (440) | (281) | (279) | ||||||||||||||
Contributions from (distribution to) noncontrolling interest | - | - | - | ||||||||||||||
Distributions from (to) noncontrolling interest | - | - | - | ||||||||||||||
Net cash used in financing activities | (7,745) | (3,433) | (5,125) | ||||||||||||||
Effect of exchange rate changes on cash and cash equivalents | 92 | (40) | 57 | ||||||||||||||
Net change in cash and cash equivalents | (2,428) | 3,906 | 673 | ||||||||||||||
Supplemental disclosure of cash flow information: | |||||||||||||||||
Interest paid, net of amounts capitalized | - | 951 | 891 | ||||||||||||||
Interest paid, net of amounts capitalized | - | - | - | ||||||||||||||
Income taxes paid | - | $ 2,779 | $ 3,990 |